Clarkson’s Disease Episode or Secondary Systemic Capillary Leak-Syndrome

Systemic capillary leak syndrome.

A 40-year-old woman was referred to our hospital with severe hypovolemic shock and anasarca. The laboratory findings showed marked hemoconcentration and a decrease in total serum protein with the presence of monoclonal IgG-lambda. She had had a similar episode of generalized edema 2 years previously. We diagnosed the patient as having typical systemic capillary leak syndrome (SCLS) and she impr...

SyStemic capillary leak Syndrome

Results: Of the 34 patients whose records were reviewed, 25 fulfilled all diagnostic criteria for SCLS. The median age at diagnosis of SCLS was 44 years. Median follow-up of surviving patients was 4.9 years, and median time to diagnosis from symptom onset was 1.1 years (interquartile range, 0.5-4.1 years). Flulike illness or myalgia was reported by 14 patients (56%) at onset of an acute attack ...

Pulmonary Capillary Leak Syndrome

Inflammatory Markers of the Systemic Capillary Leak Syndrome (Clarkson Disease)

OBJECTIVES The Systemic Capillary Leak Syndrome (SCLS) is a rare and potentially fatal disorder resembling systemic anaphylaxis that is characterized by transient episodes of hypotensive shock and peripheral edema. The pathogenesis of SCLS is unknown, and triggers for attacks are apparent only in a minority of patients. We introduce a clinical algorithm for the diagnosis of SCLS, and we investi...

[Issues about systemic capillary leak syndrome].

Quisiera agradecer a los doctores M. Molina, R. Amézaga, A. Colomar y M. Riera del Servicio de Medicina Intensiva, Hospital Universitario Son Espases, Palma de Mallorca, España, sus felicitaciones en relación con el artículo publicado en su revista «Guías de práctica clínica para el manejo del síndrome de bajo gasto cardíaco en el postoperatorio de cirugía cardíaca»1 por sus palabras, al consid...